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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK2
All Species:
38.48
Human Site:
Y464
Identified Species:
60.48
UniProt:
Q92630
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92630
NP_003574.1
601
66652
Y464
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
S
Chimpanzee
Pan troglodytes
XP_509205
601
66595
Y464
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
S
Rhesus Macaque
Macaca mulatta
XP_001117134
601
66643
Y464
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
S
Dog
Lupus familis
XP_538273
601
66656
Y464
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
S
Cat
Felis silvestris
Mouse
Mus musculus
Q5U4C9
599
66538
Y462
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
S
Rat
Rattus norvegicus
Q4V8A3
586
65492
Y450
N
S
K
G
L
P
R
Y
C
S
V
T
T
Q
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
R427
S
V
V
L
N
G
G
R
S
R
R
G
K
L
R
Chicken
Gallus gallus
Q5ZIU3
526
59419
K411
G
G
R
S
R
R
G
K
L
R
G
P
P
E
S
Frog
Xenopus laevis
NP_001088793
567
63329
Y431
N
S
K
G
Y
P
R
Y
C
T
V
T
T
L
P
Zebra Danio
Brachydanio rerio
NP_001038298
587
65453
Y451
S
S
K
G
H
P
R
Y
C
T
V
T
T
L
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
Y518
S
P
K
G
Y
P
R
Y
C
T
V
R
T
M
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023208
796
87422
M679
L
I
I
E
L
L
G
M
P
P
P
K
S
L
E
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
Y435
N
S
K
G
Q
P
R
Y
C
T
V
T
T
L
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
E352
L
E
H
L
A
M
M
E
R
V
L
G
P
L
P
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
K622
S
T
Q
K
H
R
M
K
T
I
E
E
F
C
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
99.6
98.3
N.A.
97
59.7
N.A.
78.6
81.3
64.5
83.6
N.A.
43.3
N.A.
45.7
63.7
Protein Similarity:
100
98.8
99.8
99
N.A.
98.5
71.8
N.A.
83
84.5
75
89.8
N.A.
54.9
N.A.
55.6
73.5
P-Site Identity:
100
100
100
100
N.A.
100
66.6
N.A.
13.3
6.6
86.6
86.6
N.A.
80
N.A.
6.6
80
P-Site Similarity:
100
100
100
100
N.A.
100
86.6
N.A.
13.3
13.3
93.3
93.3
N.A.
86.6
N.A.
13.3
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.3
27.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
36.6
41.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
67
0
0
0
0
7
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
7
0
7
0
0
0
7
0
0
7
7
0
7
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
7
7
0
67
0
7
20
0
0
0
7
14
0
0
0
% G
% His:
0
0
7
0
14
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
7
0
0
0
0
0
0
7
0
0
0
0
0
% I
% Lys:
0
0
67
7
0
0
0
14
0
0
0
7
7
0
0
% K
% Leu:
14
0
0
14
14
7
0
0
7
0
7
0
0
74
0
% L
% Met:
0
0
0
0
0
7
14
7
0
0
0
0
0
7
0
% M
% Asn:
20
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
7
0
0
0
67
0
0
7
7
7
7
14
0
27
% P
% Gln:
0
0
7
0
7
0
0
0
0
0
0
0
0
7
0
% Q
% Arg:
0
0
7
0
7
14
67
7
7
14
7
7
0
0
14
% R
% Ser:
60
60
0
7
0
0
0
0
7
7
0
0
7
0
47
% S
% Thr:
0
7
0
0
0
0
0
0
7
60
0
60
67
0
7
% T
% Val:
0
7
7
0
0
0
0
0
0
7
67
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
47
0
0
67
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _